Change search
ReferencesLink to record
Permanent link

Direct link
Serum 25-hydroxyvitamin D and the risk of ovarian cancer
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Clinical chemistry.
Show others and affiliations
2010 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 46, no 2, 364-369 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Ecological and experimental studies suggest that vitamin D may be associated with a reduced risk of ovarian cancer. In this study, we sought to determine the risk of developing ovarian cancer according to serum 25-hydroxyvitamin D (25-OHD) concentrations assessed on average 5 years before the diagnosis.

METHODS: We conducted a population-based longitudinal case-control study nested within the Finnish Maternity Cohort (FMC) which contains serum samples of virtually all pregnant women in Finland since 1983. Among them, 201 ovarian cancers diagnosed within 10 years of serum sampling were randomly selected as cases for this study. For each case, we selected two controls matched for age, parity and sampling season (+/-4 weeks) and one control matched for age and parity but for the opposite sampling season (6 months+/-4 weeks).

RESULTS: The relative risks (estimated as odds ratio, OR) for ovarian cancer comparing the lowest quintile to the highest quintile of serum 25-OHD concentration were 1.8 (95% CI 0.9-3.5) among controls matched for the same season, and 1.1 (95% CI 0.6-2.2) among controls matched for the opposite season. The OR among women with insufficient (<75nmol/L) serum 25-OHD concentration was 2.7 (95% CI 1.0-7.9, lower limit, 0.95) compared to that among those with sufficient (75nmol/L) serum 25-OHD concentration. No differences in the point estimates were observed between serous or mucinous histological subtypes of ovarian cancer.

CONCLUSION: Overall, we did not observe a significant association between serum 25-OHD concentrations and the risk of ovarian cancer. However, we found evidence suggestive of an increased risk among women with low to insufficient serum 25-OHD concentrations.

Place, publisher, year, edition, pages
2010. Vol. 46, no 2, 364-369 p.
Keyword [en]
Ovarian cancer; Vitamin D; 25-Hydroxyvitamin D; Nested case–control; Population-based
URN: urn:nbn:se:umu:diva-30370DOI: 10.1016/j.ejca.2009.08.002ISI: 000274123300022PubMedID: 19713101OAI: diva2:282358
Available from: 2009-12-19 Created: 2009-12-19 Last updated: 2011-09-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Grankvist, Kjell
By organisation
Clinical chemistry
In the same journal
European Journal of Cancer

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link