Regioselective Halogenations and Subsequent Suzuki-Miyaura Coupling onto Bicyclic 2-Pyridones
2010 (English)In: The Journal of organic chemistry, ISSN 1520-6904, Vol. 75, no 3, 972-5 p.Article in journal (Refereed) Published
A selective synthesis of 6-bromo-8-iodo dihydro thiazolo ring-fused 2-pyridones is described. These halogenated 2-pyridones are selectively arylated by sequential Suzuki-Miyaura couplings. This approach can advantageously be used to synthesize focused libraries of substituted ring-fused 2-pyridones, a class of compounds with novel antibacterial properties.
Place, publisher, year, edition, pages
American Chemical Society , 2010. Vol. 75, no 3, 972-5 p.
IdentifiersURN: urn:nbn:se:umu:diva-30482DOI: 10.1021/jo902458gISI: 000273982900059PubMedID: 20025251OAI: oai:DiVA.org:umu-30482DiVA: diva2:284072