umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association of exposure to ozone, formaldehyde, NO2 and terpenes with reported symptoms in office workers
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Dermatology and Venerology. Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Occupational and Enviromental Medicine. (KLUCK-projektet)
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Dermatology and Venerology.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Epidemiology and Public Health Sciences.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Occupational and Enviromental Medicine.
(English)Article in journal (Refereed) Submitted
Abstract [en]

A number of risk factors for “sick building syndrome” (SBS) are known, including poor ventilation, but the associated substances in the air that are removed by ventilation are unknown. In this study the exposure of office workers to formaldehyde, d-limonene, nitrogen dioxide, ozone and α-pinene at work and at home was measured during a working week. Data on symptoms were obtained by analyzing responses to a questionnaire and participants were divided into cases and controls. We found no significant differences in chemical exposure between cases and controls. However, correlations were found between a number of individual symptoms and exposure to specific substances or combinations of substances.

Keyword [en]
Sick building syndrome, Office; Formaldehyde; Nitrogen dioxide; Ozone
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:umu:diva-30634OAI: oai:DiVA.org:umu-30634DiVA: diva2:285104
Projects
KLUCK-projektet
Available from: 2010-01-11 Created: 2010-01-11 Last updated: 2010-01-19Bibliographically approved
In thesis
1. Methodological aspects of unspecific building related symptoms research
Open this publication in new window or tab >>Methodological aspects of unspecific building related symptoms research
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis deals with methological issues in the study of chemical exposure and sick building syndrome (SBS). SBS is a combination of general, mucosal and skin symptoms that some people experience when staying in specific buildings. The aim was to find chemical patterns associated with SBS, but also to address methological problems in such study.

The plan was to conduct a case-control study comparing the two groups’ chemical exposure, where cases were defined as those having at least one general, one mucosal and one skin symptom each week the last three months. For the planning it was necessary to know if cases and controls could be selected from the same building. If everyone in a building have the same chemical exposure it is no use to compare exposure between two persons at the same workplace. In the first paper exposure to more than 100 compounds is compared between 79 participants working in eight buildings. It was found that for the majority of compounds the variation in exposure was larger within buildings than between buildings, which means that cases and controls could be allowed to work in the same building.

The second paper is a comparison of three adsorbents usability in finding differences in chemical exposure between SBS cases and controls. This was done by using chemometrical methods but comparisons of sampled amounts, blank values and reproducibility were also done. Tenax TA was found to be the best adsorbent, hence used in the case-control study.

In recent years ozone and ozone reaction products with unsaturated volatile organic compounds (VOCs) has been in focus. Nitrogen dioxide is another gas affecting oxidation of reactive VOCs. Formaldehyde is an irritant formed when unsaturated VOCs are oxidised, and in some studies a relation with SBS has been found. In paper three the relation between personal exposure to formaldehyde, nitrogen dioxide, ozone, terpenes and SBS has been investigated among more than 200 office workers in a case control study in Umeå and Vasa. Cases (based on symptoms during the week of measurements) had lower ozone exposure than controls. No further associations were found at present exposure levels. A planed analysis of relations to VOCs could not be done due to analytical problems, and problems due to difficulties with consistent identification of compounds in a very large data set. These problems are further discussed in the thesis.

In the case-control, study participants answered questionnaires about symptoms during "the past three months", "right now" (when answering the questionnaire), and during the week of exposure measurements. In the fourth paper the stability of symptoms were compared by answers at different occasions. It was found that the case/control concept was as stable as individual symptoms. More participants with atopic disease and those 41 years old or younger changed class compared with those without atopic disease and older participants. Measurement activities appeared to make participants report more symptoms. Fatigue, dry eyes and dry skin are suggested to be symptoms with strongest, and illness/dizziness to be weakest association with IAQ.

Place, publisher, year, edition, pages
Umeå: Umeå university, 2010. 72 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1315
Keyword
Sick building syndrome, SBS, exposure measurement, GC-MS, questionnaire, symptom, variability, PCA, PLS-DA
National Category
Environmental Health and Occupational Health
Identifiers
urn:nbn:se:umu:diva-30640 (URN)978-91-7264-903-3 (ISBN)
Public defence
2010-03-04, Hörsal B, 9tr, Tandläkarhögskolan, NUS, Umeå, 09:00 (Swedish)
Opponent
Supervisors
Projects
KLUCK-projektet
Available from: 2010-01-19 Created: 2010-01-11 Last updated: 2010-01-20Bibliographically approved

Open Access in DiVA

No full text

Authority records BETA

Glas, BoStenberg, BerndtStenlund, Hans

Search in DiVA

By author/editor
Glas, BoStenberg, BerndtStenlund, Hans
By organisation
Dermatology and VenerologyOccupational and Enviromental MedicineEpidemiology and Public Health Sciences
Environmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 82 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf