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Metabolic responses in ischemic myocardium after inhalation of carbon monoxide
Anestesi, Sahlgrenska akademin, Göteborgs universitet.
Anestesi, Sahlgrenska akademin, Göteborgs universitet.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Anaesthesiology.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology.
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2009 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 53, no 8, 1036-1042 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To clarify the mechanisms of carbon monoxide (CO) tissue-protective effects, we studied energy metabolism in an animal model of acute coronary occlusion and pre-treatment with CO. METHODS: In anesthetized pigs, a coronary snare and microdialysis probes were placed. CO (carboxyhemoglobin 5%) was inhaled for 200 min in test animals, followed by 40 min of coronary occlusion. Microdialysate was analyzed for lactate and glucose, and myocardial tissue samples were analyzed for adenosine tri-phosphate, adenosine di-phosphate, and adenosine mono-phosphate. RESULTS: Lactate during coronary occlusion was approximately half as high in CO pre-treated animals and glucose levels decreased to a much lesser degree during ischemia. Energy charge was no different between groups. CONCLUSIONS: CO in the low-doses tested in this model results in a more favorable energy metabolic condition in that glycolysis is decreased in spite of maintained energy charge. Further work is warranted to clarify the possible mechanistic role of energy metabolism for CO protection.

Place, publisher, year, edition, pages
2009. Vol. 53, no 8, 1036-1042 p.
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Medical and Health Sciences
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URN: urn:nbn:se:umu:diva-30732DOI: 10.1111/j.1399-6576.2009.01992.xPubMedID: 19426237OAI: oai:DiVA.org:umu-30732DiVA: diva2:286400
Available from: 2010-01-14 Created: 2010-01-14 Last updated: 2017-12-12Bibliographically approved

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