Static blood-flow control during cardiopulmonary bypass is a compromise of oxygen delivery
2009 (English)In: European Journal of Cardio-Thoracic Surgery, ISSN 1010-7940, E-ISSN 1873-734X, Vol. 37, no 1, 218-222 p.Article in journal (Refereed) Published
Background: Blood-flow control during cardiopulmonary bypass (CPB) is by tradition based on the patient's body surface area. Emergence of new techniques enables dynamic blood-flow control based on online measurement of venous oxygen saturation and oxygen consumption. Present investigation aimed to compare static versus dynamic blood-flow control with respect to use of oxygen and effects upon organ function. Methods: In this study, 100 coronary-artery-bypass surgical patients were prospectively randomised to static or dynamic hypothermic blood-flow control during CPB. In the static group, pump flow was set to 2.4 (litres per minute) times the patient's body surface area (m(2)) throughout the procedure. Pump flow in the dynamic group was varied according to the reading of the venous oxygen saturation and maintained at >75%. CPB-specific information was collected online. Blood samples were collected for analysis of haemoglobin, lactate, amylase, creatinine and C-reactive protein: pre-CPB, at weaning from CPB and on day 1 postoperatively. Results: Randomisation formed two uniform groups. Choice of static or dynamic blood-flow control during CPB had no significant effects on organ function as judged by lactate, amylase or creatinine levels. On increasing oxygen demand, oxygen balance was maintained by increasing venous oxygen extraction rates in the static flow mode and by increasing the pump flow rate in the dynamic group. Conclusions: Independent of the blood-flow control mode, oxygen balance remained preserved. However, the dynamic mode provided higher oxygen delivery, which may increase margins of safety and protection of organ function.
Place, publisher, year, edition, pages
2009. Vol. 37, no 1, 218-222 p.
IdentifiersURN: urn:nbn:se:umu:diva-31399DOI: 10.1016/j.ejcts.2009.05.019ISBN: 1873-734X (Electronic) 1010-7940 (Linking)OAI: oai:DiVA.org:umu-31399DiVA: diva2:292950
Journal article European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Eur J Cardiothorac Surg. 2010 Jan;37(1):218-222. Epub 2009 Jul 29.2010-02-102010-02-102012-08-15Bibliographically approved