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Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Anesthesiology and Intensive Care.
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Anesthesiology and Intensive Care.ORCID iD: 0000-0002-5325-2688
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2003 (English)In: Thromb Haemost, Vol. 90, no 5, 796-802 p.Article in journal (Refereed) Published
Abstract [en]

To investigate beta2 -adrenergic agonist-mediated effects on coronary fluxes of local fibrinolytic factors, healthy anaesthetised and instrumented pigs (n=10) were studied during infusion of isoprenaline (IPR) into the left main coronary artery. Coronary net fluxes of total t-PA antigen, active t-PA and total PAI-1 antigen were determined at baseline and at 3, 5, 7 and 10 minutes of IPR infusion. During IPR, net release of total t-PA increased in a biphasic pattern with transiently high levels at 3 (+440 %) and 7 minutes (+620%) and returned towards baseline at 10 minutes. Net coronary release of active t-PA increased with maximum levels at 3 minutes (+50%). Baseline coronary net flux of total PAI -1 showed a decrease which was most pronounced at 10 minutes. To conclude, a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile.

Place, publisher, year, edition, pages
2003. Vol. 90, no 5, 796-802 p.
Keyword [en]
Adrenergic Agonists/*pharmacology, Animals, Catheterization, Coronary Vessels/*metabolism/physiology, Female, Fibrinolysis, Hemodynamics/drug effects, Isoproterenol/pharmacology, Kinetics, Plasminogen Activator Inhibitor 1/blood, Receptors, Adrenergic, beta-2/agonists/*blood, Swine, Tissue Plasminogen Activator/*blood
Identifiers
URN: urn:nbn:se:umu:diva-31403ISBN: 0340-6245 (Print) OAI: oai:DiVA.org:umu-31403DiVA: diva2:292965
Note
Osterlund, Barbro Jern, Christina Seeman-Lodding, Helene Johansson, Goran Haggmark, Soren Broome, Michael Biber, Bjorn Research Support, Non-U.S. Gov't Germany Thrombosis and haemostasis Thromb Haemost. 2003 Nov;90(5):796-802.Available from: 2010-02-10 Created: 2010-02-10 Last updated: 2015-09-15

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