Change search
ReferencesLink to record
Permanent link

Direct link
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Show others and affiliations
2010 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 42, no 2, 105-116 p.Article in journal (Refereed) Published
Abstract [en]

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.

Place, publisher, year, edition, pages
2010. Vol. 42, no 2, 105-116 p.
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:umu:diva-31566DOI: 10.1038/ng.520ISI: 000274084400005PubMedID: 20081858OAI: diva2:293352
Available from: 2010-02-11 Created: 2010-02-11 Last updated: 2015-04-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hallmans, GöranRolandsson, OlovFranks, Paul W
By organisation
Nutritional ResearchFamily MedicineMedicine
In the same journal
Nature Genetics
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 83 hits
ReferencesLink to record
Permanent link

Direct link