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Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
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2009 (English)In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 47, no 11, 2299-2304 p.Article in journal (Refereed) Published
Abstract [en]

Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson's disease). In a group of normal middle-aged adults, we examined links between PET-derived measures of D2 receptor binding in striatum, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus (HC) and IIV for tasks assessing recognition memory and executive functioning. An index of IIV, the intraindividual standard deviation (ISD), was computed across successful response latency trials for each cognitive outcome. Lower D2 binding in OC, ACC, and HC, but not striatum, was associated with increasing ISDs for the memory and executive measures. Consistent with neurocomputational models, the present findings suggest a role for extrastriatal DA neurotransmission in modulating variability in cognitive functioning.

Place, publisher, year, edition, pages
2009. Vol. 47, no 11, 2299-2304 p.
Keyword [en]
PET, Intraindividual variability, Dopamine, Executive functioning, Recognition memory
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-31996DOI: 10.1016/j.neuropsychologia.2009.01.016PubMedID: 19524093OAI: diva2:301417
Available from: 2010-03-03 Created: 2010-02-26 Last updated: 2010-06-24Bibliographically approved

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