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Modulation of striatal dopamine D1 binding by cognitive processing
Aging Research Center, Karolinska Institutet, Stockholm, Sweden. (Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden)
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden.
Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
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2009 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 48, no 2, 398-404 p.Article in journal (Refereed) Published
Abstract [en]

There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30 years) and 20 older (65-75 years) persons who underwent two [(11)C] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system.

Place, publisher, year, edition, pages
Elsevier, 2009. Vol. 48, no 2, 398-404 p.
Keyword [en]
Dopamine release, D1 binding, SCH 23390, Striatum, Aging, Cognition
National Category
Neurosciences Physiology Psychology Psychiatry
Identifiers
URN: urn:nbn:se:umu:diva-31995DOI: 10.1016/j.neuroimage.2009.06.030PubMedID: 19539768OAI: oai:DiVA.org:umu-31995DiVA: diva2:301424
Available from: 2010-03-03 Created: 2010-02-26 Last updated: 2017-12-12

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