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Dopamine D(1) receptors and age differences in brain activation during working memory
Aging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden.
Aging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden.
Aging Research Center, Karolinska Institutet, Gävlegatan 16, SE-113 30 Stockholm, Sweden.
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden.
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2011 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 32, no 10, 1849-1856 p.Article in journal (Refereed) Published
Abstract [en]

In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

Place, publisher, year, edition, pages
Elsevier, 2011. Vol. 32, no 10, 1849-1856 p.
Keyword [en]
Aging, Dopamine, D1 receptors, fMRI, Load-dependent BOLD response, Multimodal brain imaging, PET, Spatial working memory
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-31988DOI: 10.1016/j.neurobiolaging.2009.10.018ISI: 000294551000012PubMedID: 19962789OAI: oai:DiVA.org:umu-31988DiVA: diva2:301928
Available from: 2010-03-03 Created: 2010-02-26 Last updated: 2015-10-20Bibliographically approved

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Rieckmann, AnnaNyberg, Lars

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Umeå Centre for Functional Brain Imaging (UFBI)Department of Radiation SciencesDepartment of Integrative Medical Biology (IMB)
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