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Cellular mechanisms of bacterial internalization counteracted by Yersinia
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Fällman)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Fällman)
2005 (English)In: International Review of Cytology: a survey of cell biology / [ed] Kwang W. Jeon, Elsevier, 2005, Vol. 246, 135-188 p.Chapter in book (Refereed)
Abstract [en]

Upon host-cell contact, human pathogenic Yersinia species inject Yop virulence effectors into the host through a Type III secretion-and-translocation system. These virulence effectors cause a block in phagocytosis (YopE, YopT, YpkA, and YopH) and suppression of inflammatory mediators (YopJ). The Yops that block phagocytosis either interfere with the host cell actin regulation of Rho GTPases (YopE, YopT, and YpkA) or specifically and rapidly inactivate host proteins involved in signaling from the receptor to actin (YopH). The block in uptake has been shown to be activated following binding to Fc, Complement, and beta1-integrin receptors in virtually any kind of host cell. Thus, the use of Yersinia as a model system to study Yersinia-host cell interactions provides a good tool to explore signaling pathways involved in phagocytosis.

Place, publisher, year, edition, pages
Elsevier, 2005. Vol. 246, 135-188 p.
, International Review of Cell and Molecular Biology, ISSN 0074-7696 ; Vol 246
Keyword [en]
Bacterial Adhesion, Bacterial Outer Membrane Proteins/genetics/*metabolism, Bacterial Toxins/metabolism, Endocytosis/*physiology, Humans, Phagocytosis/physiology, Receptors; Fc/metabolism, Virulence Factors/administration & dosage/metabolism, Yersinia/*metabolism/pathogenicity, Yersinia Infections, rho GTP-Binding Proteins/metabolism
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-32251DOI: 10.1016/S0074-7696(05)46004-0PubMedID: 16164968ISBN: 978-0-12-364650-7OAI: diva2:302232
Available from: 2010-03-04 Created: 2010-03-04 Last updated: 2013-07-10Bibliographically approved

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Fällman, MariaGustavsson, Anna
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Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)
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