A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33.
2009 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 73, no 21, 1767-1773 p.Article in journal (Refereed) Published
OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
Place, publisher, year, edition, pages
2009. Vol. 73, no 21, 1767-1773 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-32341DOI: 10.1212/WNL.0b013e3181c34b1dPubMedID: 19933978OAI: oai:DiVA.org:umu-32341DiVA: diva2:302866