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A novel stroke locus identified in a northern Sweden pedigree: linkage to chromosome 9q31-33.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2009 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 73, no 21, 1767-1773 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.

Place, publisher, year, edition, pages
2009. Vol. 73, no 21, 1767-1773 p.
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Medical and Health Sciences
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URN: urn:nbn:se:umu:diva-32341DOI: 10.1212/WNL.0b013e3181c34b1dPubMedID: 19933978OAI: oai:DiVA.org:umu-32341DiVA: diva2:302866
Available from: 2010-03-10 Created: 2010-03-10 Last updated: 2017-12-12Bibliographically approved

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Nilsson-Ardnor, SofieStegmayr, BirgittaAsplund, KjellHolmberg, Dan

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