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The cost-burden of paediatric pneumococcal disease in Sweden and the potential cost-effectiveness of prevention using 7-valent pneumococcal vaccine.
Umeå University, Faculty of Medicine, Clinical Sciences, Paediatrics.
2009 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 27, no 10, 1601-1608 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: A cost-effectiveness model was used to estimate the change in disease burden that might be expected if PCV7 was included as part of the routine 3-dose vaccination schedule in Sweden. METHODS: An economic model was populated with data from the main clinical PCV7 efficacy trials, demographic data from government sources, surveillance and epidemiologic data from the US and Nordic region, and average treatment costs, considering the impact of disease on the whole national population. RESULTS: The model estimated that PCV7 would prevent 18,856 cases of AOM, 684 of pneumonia, 86 of pneumococcal bacteraemia and 21 cases of pneumococcal meningitis in children <10 years, further 221 cases of IPD would be avoided in older children and adults and 397 cases of pneumonia in adults aged 18-39 years. Annually, 4 childhood (<10 years) deaths and 39 deaths in older children and adults would be prevented, resulting in an annual saving of 632 life years. The reduction of cost for the society was estimated to 27.9 (-205, +160) million SEK. The sensitivity analysis showed that it was most sensitive to the efficacy of the vaccine against AOM, the cost of managing infections and the incidence of all disease. CONCLUSION: This model demonstrates that implementing a universal vaccine programme in Sweden with PCV7 would be cost-effective with an estimated net reduction of costs for the society.

Place, publisher, year, edition, pages
2009. Vol. 27, no 10, 1601-1608 p.
Keyword [en]
Immunization, Pharmacoeconomics, Paediatrics, Heptavalent pneumococcal conjugate vaccine, Streptococcus pneumoniae
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-32443DOI: 10.1016/j.vaccine.2008.12.033PubMedID: 19146905OAI: diva2:303245
Available from: 2010-03-11 Created: 2010-03-11 Last updated: 2010-04-09Bibliographically approved

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Silfverdal, Sven Arne
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