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Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms.
Umeå University, Faculty of Medicine, Molecular Biology. Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). (urban)
2006 (English)In: Cellular Microbiology, ISSN 1462-5814, E-ISSN 1462-5822, Vol. 8, no 4, 668-676 p.Article in journal (Refereed) Published
Abstract [en]

Neutrophils phagocytose and kill microbes upon phagolysosomal fusion. Recently we found that activated neutrophils form extracellular fibres that consist of granule proteins and chromatin. These neutrophil extracellular traps (NETs) degrade virulence factors and kill Gram positive and negative bacteria. Here we show for the first time that Candida albicans, a eukaryotic pathogen, induces NET-formation and is susceptible to NET-mediated killing. C. albicans is the predominant aetiologic agent of fungal infections in humans, particularly in immunocompromised hosts. One major virulence trait of C. albicans is its ability to reversibly switch from singular budding cells to filamentous hyphae. We demonstrate that NETs kill both yeast-form and hyphal cells, and that granule components mediate fungal killing. Taken together our data indicate that neutrophils trap and kill ascomycetous yeasts by forming NETs.

Place, publisher, year, edition, pages
2006. Vol. 8, no 4, 668-676 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-32551DOI: 10.1111/j.1462-5822.2005.00659.xPubMedID: 16548892OAI: oai:DiVA.org:umu-32551DiVA: diva2:304077
Available from: 2010-03-16 Created: 2010-03-16 Last updated: 2017-12-12Bibliographically approved

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