Correlations between serum progesterone and smoking, and the growth fraction of cervical squamous cell carcinoma
2000 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 20, no 5C, 3637-3640 p.Article in journal (Refereed) Published
BACKGROUND: Possible correlations between growth fraction of squamous cervical carcinomas and serum progesterone (se-P) concentrations, smoking habits and DNA ploidy were studied. MATERIALS AND METHODS: The DNA S-phase fraction (SPF), measured by flow cytometry was used as a marker of tumour growth in 103 cases of squamous cervical cancer stage IB-IV. DNA-ploidy (peridiploidy vs. aneuploidy), Se-P, se-Estradiol, smoking habits, parity, menopausal status, clinical stage and histopathological grading were compared to SPF < 14% vs. SPF > or = 14%. RESULTS: Aneuploidy, (odds ratio (OR) 10.0), se-P > or = 2.6 nmol/l (OR 7.5) and smoking (OR 3.0) were significantly associated with SPF > or = 14%, after adjustments for all factors included in the study. The association with se-P and smoking was attributed to an increased risk for the premenopausal women in the study. DISCUSSION: In this study an increased tumour growth was associated with increased leves of se-P, smoking and aneuploidy in women with invasive squamous cervical carcinoma. This study seems to experimentally confirm epidemiological studies, where smoking and long-term use of oral contraceptives have been linked to cervical neoplasms.
Place, publisher, year, edition, pages
2000. Vol. 20, no 5C, 3637-3640 p.
Medical and Health Sciences
Research subject Oncology
IdentifiersURN: urn:nbn:se:umu:diva-32590PubMedID: 11268431OAI: oai:DiVA.org:umu-32590DiVA: diva2:304294