Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides
2010 (English)In: Molecules, ISSN 1420-3049, Vol. 15, no 9, 6019-34 p.Article in journal (Refereed) Published
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
Place, publisher, year, edition, pages
2010. Vol. 15, no 9, 6019-34 p.
Type III secretion, Suzuki coupling, Grignard addition
Other Basic Medicine
IdentifiersURN: urn:nbn:se:umu:diva-32604DOI: 10.3390/molecules15096019ISI: 000282221100013OAI: oai:DiVA.org:umu-32604DiVA: diva2:304414