Improved procedure for the enantioselective synthesis of dihydrooxazolo and dihydrothiazolo ring-fused 2-pyridones
2010 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 51, no 18, 2461-2463 p.Article in journal (Refereed) Published
Improved procedures to synthesize enantioselectively analogues of a peptidomimetic scaffold with high biological relevance have been developed. Experimental design led to a general method for the preparation of dihydrooxazolo ring-fused 2-pyridones in good yields and high enantiomeric purity. The knowledge gained from this was also used to improve the microwave-accelerated synthesis of dihydrothiazolo ring-fused 2-pyridones to give complete stereo retention and high yields.
Place, publisher, year, edition, pages
Elsevier Ltd , 2010. Vol. 51, no 18, 2461-2463 p.
2-Pyridone, PPTS, Peptidomimetic, Enantioselective, Pilicide, Curlicide
IdentifiersURN: urn:nbn:se:umu:diva-32675DOI: 10.1016/j.tetlet.2010.02.162ISI: 000276972200020OAI: oai:DiVA.org:umu-32675DiVA: diva2:305050