Efficient, mild and completely regioselective synthesis of substituted pyridines
2010 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, no 19, 3384-3386 p.Article in journal (Refereed) Published
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
Place, publisher, year, edition, pages
RSC Publishing, 2010. Vol. 46, no 19, 3384-3386 p.
Molecular Structure, Organometallic Compounds, chemistry, Pyridines, chemical synthesis, chemistry, Stereoisomerism, Temperature
IdentifiersURN: urn:nbn:se:umu:diva-32684DOI: 10.1039/c000748jISI: 000277318000047OAI: oai:DiVA.org:umu-32684DiVA: diva2:305100