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Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer.
Umeå University, Faculty of Medicine, Radiation Sciences.
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Urology and Andrology.
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2009 (English)In: Clinical Cancer Research, ISSN 1078-0432, Vol. 15, no 21, 6658-6664 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: High serum levels of macrophage inhibitory cytokine 1 (MIC-1) are strongly associated with metastatic prostate cancer, suggesting MIC-1 is a biomarker for prostate cancer prognosis. EXPERIMENTAL DESIGN: We conducted a prospective cohort study of 1,442 Swedish men with a pathologically verified diagnosis of prostate cancer between 2001 and 2003. Blood was drawn either pretreatment (n = 431) or posttreatment (n = 1,011) and cases were followed for a mean time of 4.9 years (range, 0.1-6.8 years). RESULTS: MIC-1 serum levels independently predicted poor cancer-specific survival with an almost 3-fold higher cancer death rate in patients with serum levels in the highest quartile compared with men with serum levels in the lowest quartile (adjusted hazard ratio, 2.98; 95% confidence interval, 1.82-4.68). Pretreatment MIC-1 levels revealed an even stronger association with disease outcome with an 8-fold higher death rate in the highest compared with the lowest category (adjusted hazard ratio, 7.98; 95% confidence interval, 1.73-36.86). Among patients considered to have localized disease, MIC-1 significantly increased the discriminative capacity between indolent and lethal prostate cancer compared with the established prognostic markers clinical stage, pathologic grade, and prostate-specific antigen level (P = 0.016). A sequence variant in the MIC-1 gene was associated with decreased MIC-1 serum levels (P = 0.002) and decreased prostate cancer mortality (P = 0.003), suggesting a causative role of MIC-1 in prostate cancer prognosis. CONCLUSIONS: Serum MIC-1 concentration is a novel biomarker capable of predicting prostate cancer prognosis.

Place, publisher, year, edition, pages
2009. Vol. 15, no 21, 6658-6664 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-32692DOI: 10.1158/1078-0432.CCR-08-3126PubMedID: 19843661OAI: diva2:305190
Available from: 2010-03-22 Created: 2010-03-22 Last updated: 2010-03-29Bibliographically approved

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