umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bohm)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bohm)
Umeå University, Faculty of Medicine, Molecular Biology. (Berghard)
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Bohm)
2009 (English)In: Journal of Neurochemistry, ISSN 0022-3042, E-ISSN 1471-4159, Vol. 110, no 4, 1263-1275 p.Article in journal (Refereed) Published
Abstract [en]

In mouse, sexual, aggressive, and social behaviors are influenced by G protein-coupled vomeronasal receptor signaling in two distinct subsets of vomeronasal sensory neurons (VSNs): apical and basal VSNs. In addition, G protein-signaling by these receptors inhibits developmental death of VSNs. We show that cells of the vomeronasal nerve express the retinoic acid (RA) synthesizing enzyme retinal dehydrogenase 2. Analyses of transgenic mice with VSNs expressing a dominant-negative RA receptor indicate that basal VSNs differ from apical VSNs with regard to a transient wave of RA-regulated and caspase 3-mediated cell death during the first postnatal week. Analyses of G-protein subunit deficient mice indicate that RA and vomeronasal receptor signaling combine to regulate postnatal expression of Kirrel-2 (Kin of IRRE-like), a cell adhesion molecule regulating neural activity-dependent formation of precise axonal projections in the main olfactory system. Collectively, the results indicate a novel connection between pre-synaptic RA receptor signaling and neural activity-dependent events that together regulate neuronal survival and maintenance of synaptic contacts.

Place, publisher, year, edition, pages
2009. Vol. 110, no 4, 1263-1275 p.
Keyword [en]
caspase, cell survival, Kirrel, olfactory, retinoic acid, vomeronasal
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-32707DOI: 10.1111/j.1471-4159.2009.06216.xPubMedID: 19519663OAI: oai:DiVA.org:umu-32707DiVA: diva2:305416
Available from: 2010-03-23 Created: 2010-03-23 Last updated: 2017-12-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hörnberg, MariaGussing, FredrikBerghard, AnnaBohm, Staffan
By organisation
Department of Molecular Biology (Faculty of Medicine)Molecular Biology
In the same journal
Journal of Neurochemistry
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 158 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf