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Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Sports Medicine.
Umeå University, Faculty of Medicine, Integrative Medical Biology, Anatomy.
Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Sports Medicine.
Umeå University, Faculty of Medicine, Community Medicine and Rehabilitation, Rehabilitation Medicine. Umeå University, Faculty of Medicine, Surgical and Perioperative Sciences, Sports Medicine.
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2001 (English)In: Knee Surgery, Sports Traumatology, Arthroscopy, ISSN 0942-2056, E-ISSN 1433-7347, Vol. 9, no 2, 123-126 p.Article in journal (Refereed) Published
Abstract [en]

In this investigation, we show the presence of both free glutamate (microdialysis) and glutamate NMDAR1 receptors (immunohistochemical analyses of tendon biopsies), in tendons from patients with chronic Achilles tendon pain (Achilles tendinosis) and in controls (pain-free tendons). The NMDAR1 immunoreaction was usually confined to acetylcholinesterase-positive structures, implying that the reaction is present in nerves. Glutamate is a potent pain mediator in the human central nervous system, and in animals it has been shown that peripherally administered glutamate NMDA receptor antagonists diminish the response to formalin-induced nociception. Our present finding of glutamate NMDA receptors in human Achilles tendons might have implications for pain treatment.

Place, publisher, year, edition, pages
2001. Vol. 9, no 2, 123-126 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-32832DOI: 10.1007/s001670000188PubMedID: 11354854OAI: oai:DiVA.org:umu-32832DiVA: diva2:306202
Available from: 2010-03-29 Created: 2010-03-29 Last updated: 2017-12-12Bibliographically approved
In thesis
1. Badminton and the Achilles tendon
Open this publication in new window or tab >>Badminton and the Achilles tendon
2001 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2001. 73 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 758
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:umu:diva-101575 (URN)91-7305-120-9 (ISBN)
Public defence
2001-11-09, Umeå, 09:00
Opponent
Available from: 2015-04-07 Created: 2015-04-07 Last updated: 2015-04-07Bibliographically approved

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Alfredson, HåkanForsgren, StureFahlström, MartinLorentzon, Ronny

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