Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes.
2009 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 106, no 46, 19280-19285 p.Article in journal (Refereed) Published
A hallmark of acute relapsing fever borreliosis is severe bacteremia. Some Borrelia species, such as B. duttonii and B. crocidurae, associate with erythrocytes and induce aggregation recognized as erythrocyte rosetting. Erythrocyte rosettes contribute to disease severity by increased tissue invasiveness (such as invasion of CNS and encephalitis), hemorrhaging, and reduced blood flow in affected microcapillaries. Here we report that relapsing fever Borrelia binds to neolacto (Galbeta4GlcNAcbeta3Galbeta4Glcbeta1)-carrying glycoconjugates that are present on human erythrocytes. This interaction is of low affinity but is compensated for by the multivalency of neo-lacto-oligosaccharides on the erythrocyte cell surface. Hence, the protein-carbohydrate interaction is dependent on multivalent neolacto-glycans to mediate binding.
Place, publisher, year, edition, pages
2009. Vol. 106, no 46, 19280-19285 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-32838DOI: 10.1073/pnas.0905470106PubMedID: 19884498OAI: oai:DiVA.org:umu-32838DiVA: diva2:306267