Change search
ReferencesLink to record
Permanent link

Direct link
Dopamine D2 receptor SPECT with (123)I-IBZM: evaluation of collimator and post-filtering when using model-based compensation-a Monte Carlo study.
Umeå University, Faculty of Medicine, Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Radiation Sciences, Diagnostic Radiology.
2010 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 55, no 7, 1971-1988 p.Article in journal (Refereed) Published
Abstract [en]

In (123)I-IBZM brain SPECT, the main interest is the activity uptake in the striatum relative to the background, and semi-quantitative techniques using regions of interest are typically used for this purpose. Uncertainties in the measured uptakes can however be a problem due to low contrasts and high noise levels. Like SPECT in general, IBZM SPECT should benefit from reconstruction methods that include model-based compensation, but it is important that image acquisition is optimized for this technique. An important factor is the choice of collimator. In this study we compare four different parallel-hole collimators for IBZM SPECT regarding overall quantitative accuracy and measured uptake ratio as a function of image noise and uncertainty. The collimators are low-energy high-resolution (LEHR), low-energy general-purpose (LEGP), extended LEGP (ELEGP) and medium-energy general-purpose (MEGP). The effect of three Butterworth post-filters with cut-off frequencies of 0.3, 0.45 and 0.6 cm(-1) (power factor 8) is also studied. All raw-data projections are produced using Monte Carlo simulations. Of the investigated collimators, the one that is most sensitive to the primary photons, ELEGP, proved to be the most optimal for realistic noise levels. Butterworth post-filtering is advantageous, and the cut-off frequency 0.45 cm(-1) was the best compromise in this study.

Place, publisher, year, edition, pages
2010. Vol. 55, no 7, 1971-1988 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-32852DOI: 10.1088/0031-9155/55/7/012ISI: 000275756200012PubMedID: 20224163OAI: diva2:306421
Available from: 2010-03-29 Created: 2010-03-29 Last updated: 2010-04-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Larsson, AnneJakobson Mo, SusannaRiklund, Katrine
By organisation
Radiation PhysicsDiagnostic Radiology
In the same journal
Physics in Medicine and Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 77 hits
ReferencesLink to record
Permanent link

Direct link