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Antibodies to specific EBNA-1 domains and HLA DRB1*1501 interact as risk factors for multiple sclerosis.
Umeå University, Faculty of Medicine, Pharmacology and Clinical Neuroscience, Neurology.
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine). (Lundgren)
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine). (Lundgren)
2009 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 215, no 1-2, 102-107 p.Article in journal (Refereed) Published
Abstract [en]

Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein-Barr virus protein EBNA-1 and its association with HLA DRB1*1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29-36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against several EBNA-1 domains, of which antibodies against EBNA-1 (amino acid 385-420) in HLA DRB1*1501 positive individuals were associated with a 24-fold risk increase for MS. The data need confirmation in a larger sample but suggest a role for this epitope in the autoimmune pathogenesis of MS.

Place, publisher, year, edition, pages
2009. Vol. 215, no 1-2, 102-107 p.
Keyword [en]
Multiple sclerosis; Epstein–Barr virus; EBNA-1; Autoimmune diseases; HLA; Case control studies
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-32858DOI: 10.1016/j.jneuroim.2009.08.004PubMedID: 19733917OAI: oai:DiVA.org:umu-32858DiVA: diva2:306446
Available from: 2010-03-29 Created: 2010-03-29 Last updated: 2017-12-12Bibliographically approved

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Sundström, PeterNyström, MariaRuuth, KristinaLundgren, Erik
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