Antibodies to specific EBNA-1 domains and HLA DRB1*1501 interact as risk factors for multiple sclerosis.
2009 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 215, no 1-2, 102-107 p.Article in journal (Refereed) Published
Epitope reactivity of multiple sclerosis (MS) plasma antibodies against the Epstein-Barr virus protein EBNA-1 and its association with HLA DRB1*1501 status was investigated in a case-referent study. Based on EBNA-1 fragment reactivity and the effect of peptide blocking, four 29-36 amino acid long EBNA-1 fragments were selected for detailed studies. MS cases had increased antibody reactivity against several EBNA-1 domains, of which antibodies against EBNA-1 (amino acid 385-420) in HLA DRB1*1501 positive individuals were associated with a 24-fold risk increase for MS. The data need confirmation in a larger sample but suggest a role for this epitope in the autoimmune pathogenesis of MS.
Place, publisher, year, edition, pages
2009. Vol. 215, no 1-2, 102-107 p.
Multiple sclerosis; Epstein–Barr virus; EBNA-1; Autoimmune diseases; HLA; Case control studies
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-32858DOI: 10.1016/j.jneuroim.2009.08.004PubMedID: 19733917OAI: oai:DiVA.org:umu-32858DiVA: diva2:306446