Synthesis of 14C Sarin
2003 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 6, 599-604 p.Article in journal (Refereed) Published
Synthetic routes for the synthesis of [14C] sarin and related nerve agents are described. Triethyl phosphite and [14C] methyl iodide are reacted in the Michaelis-Arbusov reaction to produce diethyl methyl phosphonate which is converted to methylphosphonic acid by hydrolysis. After chlorination and subsequent fluorination the final product is formed by reaction with the appropriate alcohol.
Place, publisher, year, edition, pages
Wiley Interscience , 2003. Vol. 6, 599-604 p.
synthesis, o-isopropyl methylphosphonofluoridate, [14C] sarin synthesis, chemical warfare agents, O-isopropyl methyl phosphono fluoridate
Other Basic Medicine
IdentifiersURN: urn:nbn:se:umu:diva-32899DOI: 10.1002/jlcr.699OAI: oai:DiVA.org:umu-32899DiVA: diva2:306601
Rikard Norlin = Rikard Wärme2010-03-302010-03-302010-04-06Bibliographically approved