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Calcium regulation of basic helix-loop-helix transcription factors
Department of Biosciences, Karolinska institute, Novum, Huddinge, Sweden.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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1998 (English)In: Cell Calcium, ISSN 0143-4160, E-ISSN 1532-1991, Vol. 23, no 2-3, 135-142 p.Article in journal (Refereed) Published
Abstract [en]

The basic helix-loop-helix (bHLH) family of transcription factors is essential for numerous developmental and growth control processes. The regulation of bHLH proteins occurs at many levels, including tissue specific expression, differential oligomerization and DNA binding specificities, interaction with negatively acting HLH proteins and post-translational modifications. This review focuses on what is emerging as another level of bHLH protein regulation, calcium regulation through interaction with Ca2+ loaded calmodulin and S-100 proteins. The mechanism and implications of these Ca2+ regulated interactions are discussed.

Place, publisher, year, edition, pages
Elsevier, 1998. Vol. 23, no 2-3, 135-142 p.
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-33077DOI: 10.1016/S0143-4-4160(98)90112-9PubMedID: 9601609OAI: oai:DiVA.org:umu-33077DiVA: diva2:309932
Available from: 2010-04-09 Created: 2010-04-09 Last updated: 2017-12-12Bibliographically approved

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Grundström, Thomas

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