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AML and Ets proteins regulate the I alpha1 germ-line promoter.
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine).
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1999 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 29, no 2, 488-498 p.Article in journal (Refereed) Published
Abstract [en]

The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active. Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions. The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus. Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity. Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.

Place, publisher, year, edition, pages
1999. Vol. 29, no 2, 488-498 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-33075DOI: 10.1002/(SICI)1521-4141(199902)29:02<488::AID-IMMU488>3.0.CO;2-NPubMedID: 10064064OAI: oai:DiVA.org:umu-33075DiVA: diva2:309936
Available from: 2010-04-09 Created: 2010-04-09 Last updated: 2017-12-12Bibliographically approved

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