AML and Ets proteins regulate the I alpha1 germ-line promoter.
1999 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 29, no 2, 488-498 p.Article in journal (Refereed) Published
The immunoglobulin heavy chain (IgH) class switch recombination of B lymphocytes preferentially targets unrearranged IgH genes that have already been rendered transcriptionally active. Transcription of the germ-line IgH genes is controlled by intervening (I) regions upstream of their switch regions. The I alpha1 promoter activates transcription of the human germ-line C alpha1 gene for IgA1 and mediates the transforming growth factor (TGF)-beta1 responsiveness of this locus. Here we show that the I alpha1 promoter contains several binding sites for the AML/PEBP2/CBF family of transcription factors and that AML and Ets proteins are major regulators of the basal and TGF-beta-inducible promoter activity. Our data constitute a starting point for studies to elucidate the molecular mechanism by which TGF-beta regulates IgA production.
Place, publisher, year, edition, pages
1999. Vol. 29, no 2, 488-498 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-33075DOI: 10.1002/(SICI)1521-4141(199902)29:02<488::AID-IMMU488>3.0.CO;2-NPubMedID: 10064064OAI: oai:DiVA.org:umu-33075DiVA: diva2:309936