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Anaplastic lymphoma kinase: signalling in development and disease.
Umeå University, Faculty of Science and Technology, Molecular Biology (Faculty of Science and Technology). (Palmer)
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine). (Grabbe)
Umeå University, Faculty of Medicine, Molecular Biology (Faculty of Medicine). (Hallberg)
2009 (English)In: Biochemical Journal, ISSN 0264-6021, E-ISSN 1470-8728, Vol. 420, no 3, 345-361 p.Article in journal (Refereed) Published
Abstract [en]

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are constitutively enhanced by point mutation, amplification or rearrangement of the corresponding genes. The ALK (anaplastic lymphoma kinase) RTK was originally identified as a member of the insulin receptor subfamily of RTKs that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL (anaplastic large cell lymphoma). To date, many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. Recent reports of the EML4 (echinoderm microtubule-associated protein like 4)-ALK oncoprotein in NSCLC (non-small cell lung cancer), together with the identification of activating point mutations in neuroblastoma, have highlighted ALK as a significant player and target for drug development in cancer. In the present review we address the role of ALK in development and disease and discuss implications for the future.

Place, publisher, year, edition, pages
2009. Vol. 420, no 3, 345-361 p.
Keyword [en]
anaplastic lymphoma kinase (ALK), anaplastic large cell lymphoma (ALCL), extracellular-signal-regulated kinase (ERK), inflammatory myofibroblastic tumour (IMT), midkine, neuroblastoma, non-small cell lung cancer (NSLCL), pleiotrophin
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-33087DOI: 10.1042/BJ20090387PubMedID: 19459784OAI: diva2:310038
Available from: 2010-04-12 Created: 2010-04-12 Last updated: 2010-04-12Bibliographically approved

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Palmer, Ruth HGrabbe, CarolineHallberg, Bengt
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