Control of Listeria monocytogenes virulence by 5´-untranslated RNA
2006 (English)In: Trends in Microbiology, ISSN 0966-842X, E-ISSN 1878-4380, Vol. 14, no 7, 294-298 p.Article in journal (Refereed) Published
The Gram-positive bacterium Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. Expression of five of these factors has previously been shown to be subjected to posttranscriptional regulation as a result of their long 5´-untranslated region (5´-UTR). We have investigated the presence of 5´-UTRs among the other known virulence genes and genes that encode putatively virulence-associated surface proteins. Our results strongly suggest that L. monocytogenes controls many of its virulence genes by a mechanism that involves the 5´-UTR. These findings further emphasize the importance of post-transcriptional control for L. monocytogenes virulence.
Place, publisher, year, edition, pages
2006. Vol. 14, no 7, 294-298 p.
5´-UTRs, Listeria monocytogenes, virulence genes
Biochemistry and Molecular Biology
Research subject Molecular Biology
IdentifiersURN: urn:nbn:se:umu:diva-33106DOI: 10.1016/j.tim.2006.05.001OAI: oai:DiVA.org:umu-33106DiVA: diva2:310105