c-Met expression in primary tumors and their corresponding distant metastases
2009 (English)In: Molecular Medicine Reports, ISSN 1791-2997, Vol. 1, no 6, 787-790 p.Article in journal (Refereed) Published
c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.
Place, publisher, year, edition, pages
Umeå, 2009. Vol. 1, no 6, 787-790 p.
c-Met, colorectal cancer, metastasis
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-33121DOI: 10.3892/mmr_00000029OAI: oai:DiVA.org:umu-33121DiVA: diva2:310162