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c-Met expression in primary tumors and their corresponding distant metastases
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2009 (English)In: Molecular Medicine Reports, ISSN 1791-2997, Vol. 1, no 6, 787-790 p.Article in journal (Refereed) Published
Abstract [en]

c-Met is a receptor tyrosine kinase that has beenimplicated in the pathogenesis and growth of a wide variety ofhuman malignancies, including CRC, but its role in metastasisis largely unknown. We compared c-Met expression in primaryhuman colorectal carcinomas and distant metastases from thesame patients. Formalin-fixed paraffin-embedded tissuesamples from 69 colorectal cancer patients were obtained. Theprotein expression of c-Met was evaluated immunohistochemicallyusing a commercial antibody. The difference inexpression between primary tumors and their correspondingdistant metastases was analyzed using the Wilcoxon signedranktest. c-Met expression was statistically significantlylower in the distant metastases compared to their correspondingprimary tumors (p<0.001), whereas no difference was foundbetween lymph node metastases and their correspondingprimary tumors (p=0.957). The degree of c-Met expressionwas not related to clinicopathological characteristics such astumor grade and Dukes' stage at the time of primary tumordiagnosis, or to the location of the distant metastases. Wedemonstrated that c-Met expression is often reduced in distantmetastases compared to their corresponding primary colorectaltumors. Additional studies of c-Met activation and signaltransduction will increase our knowledge about the role ofc-Met in colorectal cancer metastasis.

Place, publisher, year, edition, pages
Umeå, 2009. Vol. 1, no 6, 787-790 p.
Keyword [en]
c-Met, colorectal cancer, metastasis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-33121DOI: 10.3892/mmr_00000029OAI: oai:DiVA.org:umu-33121DiVA: diva2:310162
Available from: 2010-04-13 Created: 2010-04-13 Last updated: 2015-03-24Bibliographically approved

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Van Guelpen, BethanyStenling, RogerPalmqvist, RichardHenriksson, Maria L

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Isaksson-Mettävainio, MartinVan Guelpen, BethanyÖberg, ÅkeStenling, RogerPalmqvist, RichardHenriksson, Maria L
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