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Targeting exported substrates to the Yersinia TTSS: different functions for different signals?
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
2001 (English)In: Trends in Microbiology, ISSN 0966-842X, E-ISSN 1878-4380, Vol. 9, no 8, 367-371 p.Article in journal (Refereed) Published
Abstract [en]

Many Gram-negative pathogens utilize a type III secretion system (TTSS) to inject toxins into the cytosol of eukaryotic cells. Previous studies have indicated that exported substrates are targeted to the Yersinia TTSS via the coding regions of their 5' mRNA sequences, as well as by their cognate chaperones. However, recent results from our laboratory have challenged the role of mRNA targeting signals, as we have shown that the amino termini of exported substrates are crucial for type III secretion. Here, we discuss the nature of these amino-terminal secretion signals and propose a model for the secretion of exported substrates by amino-terminal and chaperone-mediated signals. In addition, we discuss the roles of chaperones as regulators of virulence gene expression and present models suggesting that such regulation can occur independently of the delivery of their substrates to the secretion apparatus.

Place, publisher, year, edition, pages
2001. Vol. 9, no 8, 367-371 p.
Keyword [en]
Yersinia, type III, secretion, Yops, chaperones, secretion signals, flagella
Identifiers
URN: urn:nbn:se:umu:diva-33358DOI: doi:10.1016/S0966-842X(01)02100-XPubMedID: 11514218OAI: oai:DiVA.org:umu-33358DiVA: diva2:311631
Available from: 2010-04-22 Created: 2010-04-22 Last updated: 2017-12-12Bibliographically approved

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Forsberg, ÅkeWolf-Watz, HansFrancis, Matthew S
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