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The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Medicine, Molecular Biology.
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
1997 (English)In: EMBO Journal, ISSN 0261-4189, E-ISSN 1460-2075, Vol. 16, no 9, 2307-2318 p.Article in journal (Refereed) Published
Abstract [en]

Pathogenic Yersinia resist uptake by eukaryotic cells by a mechanism involving the virulence protein YopH, a protein tyrosine phosphatase. We show that p130Cas and FAK are phosphorylated and recruited to peripheral focal complexes during bacterial uptake in HeLa cells. The inactive form of YopH interacts with the tyrosine phosphorylated forms of FAK and p130Cas and co-localizes with these proteins in focal adhesions. On the other hand, the presence of active YopH results in inhibition of uptake, dephosphorylation of p130Cas and FAK, and disruption of peripheral focal complexes. We suggest that p130Cas and FAK are substrates for YopH and that the dephosphorylation of these proteins impairs the uptake of Yersinia pseudotuberculosis into HeLa cells.

Place, publisher, year, edition, pages
1997. Vol. 16, no 9, 2307-2318 p.
Keyword [en]
FAK, focal adhesions, p130Cas, Yersinia, YopH
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-33371DOI: 10.1093/emboj/16.9.2307PubMedID: 9171345OAI: oai:DiVA.org:umu-33371DiVA: diva2:311641
Available from: 2010-04-22 Created: 2010-04-22 Last updated: 2013-02-06Bibliographically approved
In thesis
1. Interactions between Yersinia pseudotuberculosis and host cells - role of invasin and YopH
Open this publication in new window or tab >>Interactions between Yersinia pseudotuberculosis and host cells - role of invasin and YopH
1999 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 1999. 72 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 634
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:umu:diva-65079 (URN)91-7191-732-2 (ISBN)
Public defence
Föreläsningssalen, Institutionen för mikrobiologi, Umeå universitet, Umeå (English)
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retroaktiv registrering

Available from: 2013-02-06 Created: 2013-02-05 Last updated: 2013-02-06Bibliographically approved

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Persson, CathrineCarballeira, NiviaWolf-Watz, HansFällman, Maria

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