An overview of RNAs with regulatory functions in gram-positive bacteria.
2010 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 67, no 2, 217-237 p.Article in journal (Refereed) Published
During the last decade, RNA molecules with regulatory functions on gene expression have benefited from a renewed interest. In bacteria, recent high throughput computational and experimental approaches have led to the discovery that 10-20% of all genes code for RNAs with critical regulatory roles in metabolic, physiological and pathogenic processes. The trans-acting RNAs comprise the noncoding RNAs, RNAs with a short open reading frame and antisense RNAs. Many of these RNAs act through binding to their target mRNAs while others modulate protein activity or target DNA. The cis-acting RNAs include regulatory regions of mRNAs that can respond to various signals. These RNAs often provide the missing link between sensing changing conditions in the environment and fine-tuning the subsequent biological responses. Information on their various functions and modes of action has been well documented for gram-negative bacteria. Here, we summarize the current knowledge of regulatory RNAs in gram-positive bacteria.
Place, publisher, year, edition, pages
Basel: Birkhäuser Vlg , 2010. Vol. 67, no 2, 217-237 p.
Gene Expression Regulation, Bacterial Gram-Positive Bacteria RNA, Bacterial RNA, Untranslated Virulence
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-33408DOI: 10.1007/s00018-009-0162-8ISI: 000273310400004PubMedID: 19859665OAI: oai:DiVA.org:umu-33408DiVA: diva2:311719