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An overview of RNAs with regulatory functions in gram-positive bacteria.
Architecture et Re´activite´ de l’ARN, Universite´ de Strasbourg, Strasbourg, France.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). (Charpentier)
2010 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 67, no 2, 217-237 p.Article in journal (Refereed) Published
Abstract [en]

During the last decade, RNA molecules with regulatory functions on gene expression have benefited from a renewed interest. In bacteria, recent high throughput computational and experimental approaches have led to the discovery that 10-20% of all genes code for RNAs with critical regulatory roles in metabolic, physiological and pathogenic processes. The trans-acting RNAs comprise the noncoding RNAs, RNAs with a short open reading frame and antisense RNAs. Many of these RNAs act through binding to their target mRNAs while others modulate protein activity or target DNA. The cis-acting RNAs include regulatory regions of mRNAs that can respond to various signals. These RNAs often provide the missing link between sensing changing conditions in the environment and fine-tuning the subsequent biological responses. Information on their various functions and modes of action has been well documented for gram-negative bacteria. Here, we summarize the current knowledge of regulatory RNAs in gram-positive bacteria.

Place, publisher, year, edition, pages
Basel: Birkhäuser Vlg , 2010. Vol. 67, no 2, 217-237 p.
Keyword [en]
Gene Expression Regulation, Bacterial Gram-Positive Bacteria RNA, Bacterial RNA, Untranslated Virulence
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-33408DOI: 10.1007/s00018-009-0162-8ISI: 000273310400004PubMedID: 19859665OAI: diva2:311719
Available from: 2010-04-22 Created: 2010-04-22 Last updated: 2011-07-08Bibliographically approved

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Charpentier, Emmanuelle
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Department of Molecular Biology (Faculty of Medicine)Molecular Infection Medicine Sweden (MIMS)Umeå Centre for Microbial Research (UCMR)
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