Iron stores and HFE genotypes are not related to increased risk of first-time myocardial infarction: a prospective nested case-referent study
2011 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 150, no 2, 169-172 p.Article in journal (Refereed) Published
Objectives: Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction.
Methods: First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined.
Results: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction.
Conclusions: No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
Place, publisher, year, edition, pages
2011. Vol. 150, no 2, 169-172 p.
myocardial infarction, iron, ferritin, HFE, prospective
Cardiac and Cardiovascular Systems Public Health, Global Health, Social Medicine and Epidemiology
Research subject Clinical Chemistry
IdentifiersURN: urn:nbn:se:umu:diva-33750DOI: 10.1016/j.ijcard.2010.04.001PubMedID: 20447705OAI: oai:DiVA.org:umu-33750DiVA: diva2:317807