Symptomatic anastomotic leakage diagnosed after hospital discharge following low anterior resection for cancer.
2009 (English)In: Colorectal Disease, ISSN 1462-8910, E-ISSN 1463-1318Article in journal (Refereed) Published
Background: The aim of this study was to investigate patients with symptomatic anastomotic leakage diagnosed after hospital discharge. Methods: Patients undergoing low anterior resection of the rectum for cancer (n=234) who were included in a prospective multicenter trial (NCT 00636948) and who developed symptomatic anastomotic leakage diagnosed after hospital discharge (late leakage, LL; n=18) were identified. These patients were assessed in regard to patient characteristics, operative details, recovery on postoperative day five, length of hospital stay, and how the leakage was diagnosed. A comparison with those who did not develop symptomatic leakage (no leakage, NL; n=189) was performed. Minimum follow up was 24 months. Results: Median age was 69 years, 61% were females, and 6% had UICC cancer stage IV in LL. On postoperative day 5, LL had a postoperative course similar to NL in regard to morning temperature, per oral intake and bowel activity. The proportion of patients being on antibiotic treatment on postoperative day 5, regardless of indication, was 28% in LL compared with 4% in NL (P<0.001). The initial hospital stay was median 10 days for both LL and NL. If adding readmission for any reason, planned or unplanned, hospital stay was median 21.5 and 13 days in LL and NL, respectively (P<0.001). Conclusion: Symptomatic anastomotic leakage diagnosed after hospital discharge following low anterior resection of the rectum for cancer is not uncommon and has an immediate clinical postoperative course which may appear uneventful.
Place, publisher, year, edition, pages
Symptomatic anastomotic leakage, clinical leakage, late leakage, low anterior resection of the rectum, postoperative course, hospital stay
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-34144DOI: 10.1111/j.1463-1318.2009.01938.xPubMedID: 19594606OAI: oai:DiVA.org:umu-34144DiVA: diva2:319158
E-pub ahead of print2010-05-142010-05-142010-05-15Bibliographically approved