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The use of a novel ELISA method for detection of antibodies against p63 in sera from patients diagnosed with oral and/or genital and skin lichen planus.
Umeå University, Faculty of Medicine, Department of Odontology, Endodontics.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology. (Karin Nylander)
Umeå University, Faculty of Medicine, Department of Odontology.
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2010 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714Article in journal (Refereed) Published
Abstract [en]

Lichen planus is a chronic inflammatory disease of mucosa and skin affecting approximately 1-2% of the adult population. Autoimmunity has been implicated in the etiology of this disease, and recently we detected antibodies directed against all six p63 isoforms in sera from 2 out of 20 patients diagnosed with oral lichen planus (OLP) using Western blot analysis. Here we have developed an ELISA method for screening sera for presence of autoantibodies directed against p63. Using the same sera as previously analysed, we show that the optical density ratios for sera from the two patients with known autoantibodies was considerably higher compared to mean optical density ratios for all samples as well as controls analysed. Applying this novel ELISA technique for screening of sera from an additional group of 46 patients with oral and/or genital or skin lichen and 43 matched controls, we detected another three patients with autoantibodies against the p63 proteins. These data are discussed together with the observation that all five patients with detectable p63 autoantibodies from our two studies had clinically severe disease symptoms.

Place, publisher, year, edition, pages
Keyword [en]
autoantibodies, ELISA, oral lichen planus, p63
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-34152DOI: 10.1111/j.1600-0714.2010.00890.xISI: 000279449100008PubMedID: 20456621OAI: diva2:319208
E-pub ahead of printAvailable from: 2010-05-15 Created: 2010-05-15 Last updated: 2011-08-31Bibliographically approved

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Ebrahimi, MajidNylander, ElisabetBäcklund, BodilWahlin, Ylva-BrittNylander, Karin
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EndodonticsDermatology and VenerologyPathologyDepartment of Odontology
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Journal of Oral Pathology & Medicine
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