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The use of a novel ELISA method for detection of antibodies against p63 in sera from patients diagnosed with oral and/or genital and skin lichen planus.
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi, Endodonti.
Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Dermatologi och venereologi.
Umeå universitet, Medicinska fakulteten, Institutionen för medicinsk biovetenskap, Patologi. (Karin Nylander)
Umeå universitet, Medicinska fakulteten, Institutionen för odontologi.
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2010 (Engelska)Ingår i: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Lichen planus is a chronic inflammatory disease of mucosa and skin affecting approximately 1-2% of the adult population. Autoimmunity has been implicated in the etiology of this disease, and recently we detected antibodies directed against all six p63 isoforms in sera from 2 out of 20 patients diagnosed with oral lichen planus (OLP) using Western blot analysis. Here we have developed an ELISA method for screening sera for presence of autoantibodies directed against p63. Using the same sera as previously analysed, we show that the optical density ratios for sera from the two patients with known autoantibodies was considerably higher compared to mean optical density ratios for all samples as well as controls analysed. Applying this novel ELISA technique for screening of sera from an additional group of 46 patients with oral and/or genital or skin lichen and 43 matched controls, we detected another three patients with autoantibodies against the p63 proteins. These data are discussed together with the observation that all five patients with detectable p63 autoantibodies from our two studies had clinically severe disease symptoms.

Ort, förlag, år, upplaga, sidor
2010.
Nyckelord [en]
autoantibodies, ELISA, oral lichen planus, p63
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:umu:diva-34152DOI: 10.1111/j.1600-0714.2010.00890.xISI: 000279449100008PubMedID: 20456621OAI: oai:DiVA.org:umu-34152DiVA, id: diva2:319208
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E-pub ahead of printTillgänglig från: 2010-05-15 Skapad: 2010-05-15 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Ebrahimi, MajidNylander, ElisabetBäcklund, BodilWahlin, Ylva-BrittNylander, Karin

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Ebrahimi, MajidNylander, ElisabetBäcklund, BodilWahlin, Ylva-BrittNylander, Karin
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EndodontiDermatologi och venereologiPatologiInstitutionen för odontologi
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Journal of Oral Pathology & Medicine
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