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Can the prevalence of open-angle glaucoma be estimated from a retrospective clinical material? A study on the west coast of Iceland.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
Rejykjavik, Island.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2005 (English)In: Acta Ophthalmologica Scandinavica, ISSN 1395-3907, E-ISSN 1600-0420, Vol. 83, no 5, 549-553 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To explore the possibility of estimating the prevalence of open-angle glaucoma (OAG) on the west coast of Iceland using a clinical retrospective material, and to compare that estimate with the results from a recent prospective Icelandic study.

METHODS: The compulsory ophthalmological examination for the prescription of eye glasses in combination with information obtained from Statistics Iceland were used to establish the prevalence of glaucoma in Akranes and to estimate the minimum prevalence for the greater west coast area. A recent prospective study from Iceland was used as reference.

RESULTS: In all, 79% of 1443 Akranes inhabitants aged 50 years or more had visited the eye clinic at least once between 1996 and 2001. The prevalence of OAG was 4.8% (95% CI 3.6-6.1). The minimum prevalence for the west coast was 3.8% (95% CI 3.2-4.4). The prevalence increased with age (p < 0.001). The overall prevalence was similar to that of recently published prospective data but the prevalence of normal tension glaucoma (NTG) was lower.

CONCLUSION: The results from the two studies are similar in many respects, which indicates that retrospective data may supply meaningful information on glaucoma prevalence. Important sources of error are the selection and attendance of patients, screening methods and diagnostic criteria. If routine examination does not include fundus photography and/or perimetry, the prevalence of NTG will be underestimated.

Place, publisher, year, edition, pages
2005. Vol. 83, no 5, 549-553 p.
Keyword [en]
applanation resonance tonometry, glaucoma, IOP
National Category
Research subject
URN: urn:nbn:se:umu:diva-34205DOI: 10.1111/j.1600-0420.2005.00514.xPubMedID: 16187991Local ID: 744OAI: diva2:319943
Available from: 2010-05-20 Created: 2010-05-20 Last updated: 2011-02-25Bibliographically approved
In thesis
1. Intraocular pressure: clinical aspects and new measurement methods
Open this publication in new window or tab >>Intraocular pressure: clinical aspects and new measurement methods
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Intraocular pressure (IOP) measurement is a routine procedure and a fundament in glaucoma care. Elevated IOP is the main risk factor for glaucoma, and to date, reduction of IOP is the only possible treatment.

In a retrospective clinical material, the prevalence of open angle glaucoma was estimated on the west coast of Iceland. IOP measurement and optic nerve head examination were used to capture glaucoma suspects, within the compulsory ophthalmological examination for the prescription of eye glasses. The results were mainly in agreement with a recent prospective study in the same region. This indicated that retrospective data, under certain conditions, may contribute with useful information on the prevalence of glaucoma. However, normal tension glaucoma is underestimated if perimetry and/or fundus photography are not included in the examination.

Three studies focused on the measurement of IOP. Goldmann applanation tonometry (GAT) is the standard method. GAT is affected by corneal properties, e.g. central corneal thickness (CCT) and corneal curvature (CC). Refractive surgery changes these properties. This has put focus on how corneal biomechanics translate into tonometric errors and stimulated the development of new methods. As a result, Pascal

® Dynamic Contour Tonometry (PDCT) and Icare® rebound tonometry have been introduced. A method under development by our research group is Applanation Resonance Tonometry (ART). It is based on resonance technology and estimates IOP from continuous measurement of force and contact area.

Comparison of PDCT, Icare and GAT in a prospective study showed that the concordance to GAT was close to the limits set by the International Standard Organization (ISO) for PDCT, while Icare was outside the limits.

To investigate if laser-assisted subepithelial keratectomy (LASEK) affects tonometry, a study was performed where measurements with GAT, PDCT and ART were obtained before, three and six months after LASEK. The hypothesis was that PDCT and ART would be less affected by LASEK than GAT. The results showed a statistically significant reduction of measured IOP three and six months after LASEK for all tonometry methods. Change in visual acuity and IOP between three and six months suggested a prolonged postoperative process.

A servo-controlled prototype (ART

servo) was developed. A study was undertaken to assess the agreement of ARTservo and a further developed v

manual prototype (ART

manual) with GAT. The study design was in accordance with the requirements of the ISO standard for tonometers. ARTmanual fulfilled the precision requirements of the ISO standard. ARTservo did not meet all the requirements of the standard at the highest pressure levels.

Four tonometry methods, GAT, PDCT, Icare and ART, were investigated. None of them was independent of both CCT and CC. The inconsistencies in the results emphasize the importance of study design. A meta-analysis comprising healthy eyes (IOP ≤ 21 mmHg) in the three papers, revealed age as an important confounder.

In summary, glaucoma prevalence in Iceland was investigated and the results indicated that a retrospective approach can contribute with meaningful information. ART and PDCT had a similar agreement to GAT. ART

manual fulfilled the precision requirements set by the ISO-standard, ARTservo and PDCT were close, while Icare was distinctly outside the limits. All tonometry methods were affected by LASEK and no method was completely independent of corneal properties.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2011. 44 p.
Umeå University medical dissertations, ISSN 0346-6612 ; 1395
Intraocular pressure, glaucoma, tonometry, ISO, LASEK, CCT, curvature
National Category
Research subject
urn:nbn:se:umu:diva-40383 (URN)978-91-7459-132-3 (ISBN)
Public defence
2011-03-18, Bergasalen, Norrlands universitetssjukhus, Umeå, 14:04 (Swedish)
Available from: 2011-02-25 Created: 2011-02-22 Last updated: 2011-02-25Bibliographically approved

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