Synthesis of 2-(2-Aminopyrimidine)-2,2-difluoroethanols as Potential Bioisosters of Salicylidene Acylhydrazides
2010 (English)In: Molecules, ISSN 1420-3049, Vol. 15, no 6, 4207-12 p.Article in journal (Refereed) Published
Salicylidene acylhydrazides are inhibitors of type III secretion in several Gramnegative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-aminopyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to thesalicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-aminopyrimidine)-2,2-difluoro-ethanols is described in this paper.
Place, publisher, year, edition, pages
2010. Vol. 15, no 6, 4207-12 p.
scaffold hopping, Reformatsky reaction, salicylidene acylhydrazide, type III secretion
IdentifiersURN: urn:nbn:se:umu:diva-34860DOI: 10.3390/molecules15064423ISI: 000279207300043OAI: oai:DiVA.org:umu-34860DiVA: diva2:326141