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Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
2002 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 76, no 1, 198-204 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Iron supplements are often recommended for older breast-fed infants, but little is known about factors affecting iron absorption from human milk or supplements. OBJECTIVE: We investigated the effects of age, iron status, and iron intake on iron absorption in healthy, term, breast-fed infants. DESIGN: Twenty-five infants were randomly assigned to receive either 1) iron supplements (1 mg x kg(-1) x d(-1)) from 4 to 9 mo of age, 2) placebo from 4 to 6 mo and iron supplements from 6 to 9 mo, or 3) placebo from 4 to 9 mo. Infants were exclusively breast-fed to 6 mo and partially breast-fed to 9 mo of age. Iron absorption was assessed by giving (58)Fe with mother's milk at 6 and 9 mo. Blood samples were obtained at 4, 6, and 9 mo, and complementary food intake was recorded at 9 mo. RESULTS: At 6 mo, mean (+/-SD) fractional iron absorption from human milk was relatively low (16.4 +/- 11.4%), with no significant difference between iron-supplemented and unsupplemented infants. At 9 mo, iron absorption from human milk remained low in iron-supplemented infants (16.9 +/- 9.3%) but was higher (P = 0.01) in unsupplemented infants (36.7 +/- 18.9%). Unexpectedly, iron absorption at 9 mo was not correlated with iron status but was significantly correlated with intake of dietary iron, including supplemental iron. CONCLUSIONS: Changes in the regulation of iron absorption between 6 and 9 mo enhance the infant's ability to adapt to a low-iron diet and provide a mechanism by which some, but not all, infants avoid iron deficiency despite low iron intakes in late infancy.

Place, publisher, year, edition, pages
American Society for Clinical Nutrition , 2002. Vol. 76, no 1, 198-204 p.
Keyword [en]
Infants, human milk, breast milk, nonheme-iron absorption, stable isotopes, iron status, dietary iron intake, complementary food, iron supplements, dietary regulator, adaptation
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:umu:diva-35001PubMedID: 12081835OAI: oai:DiVA.org:umu-35001DiVA: diva2:327485
Available from: 2010-06-29 Created: 2010-06-29 Last updated: 2015-01-22Bibliographically approved
In thesis
1. Iron requirements of term, breast-fed infants: a study in Sweden and Honduras
Open this publication in new window or tab >>Iron requirements of term, breast-fed infants: a study in Sweden and Honduras
2001 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2001. 55 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 759
National Category
Pediatrics
Identifiers
urn:nbn:se:umu:diva-96893 (URN)91-7305-129-2 (ISBN)
Public defence
2001-11-30, Tandläkarhögskolan Umeå, sal B, 9 tr., Umeå universitet, Umeå, 09:00
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digitalisering@umu
Note

Diss. (sammanfattning) Umeå : Umeå universitet, 2001

Available from: 2015-01-22 Created: 2014-12-05 Last updated: 2015-04-08Bibliographically approved

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Domellöf, MagnusHernell, Olle

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