Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia
1999 (English)In: Experimental Hematology, ISSN 0301-472X, E-ISSN 1873-2399, Vol. 27, no 4, 682-688 p.Article in journal (Refereed) Published
In this study, a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia with an early onset and high incidence was established and characterized. All tumors analyzed were found to express the alpha,beta T-cell receptor, and the majority of them had a mature, CD3+CD4+CD8- immunophenotype. In a few cases, tumors with a more immature CD3+CD4+CD8+ phenotype were isolated. Expanded phenotyping using a broad panel of lymphocyte differentiation markers confirmed the mature T-cell phenotype of the tumors. Histologic and cell cycle analysis of the tumors revealed an aggressive lymphoblastic malignancy with a very high proliferation rate and widespread engagement of bone marrow and lymphoid as well as nonlymphoid organs. Thus, the TLL mouse strain represents a unique model for the analysis of the oncogenesis and progression of mature T-cell tumors and for the development of therapeutic measures to combat such tumors.
Place, publisher, year, edition, pages
1999. Vol. 27, no 4, 682-688 p.
T-cell lymphoma, t-cell leukemia, cd3 antigen, cd4 antigen, cd8 antigen
Cancer and Oncology
Research subject Oncology
IdentifiersURN: urn:nbn:se:umu:diva-35017DOI: 10.1016/S0301-472X(99)00003-XPubMedID: 10210326OAI: oai:DiVA.org:umu-35017DiVA: diva2:328261