Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL).
2010 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 102, no 5, 796-8 p.Article in journal (Refereed) Published
BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA. RESULTS: Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL. CONCLUSION: Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia.
Place, publisher, year, edition, pages
2010. Vol. 102, no 5, 796-8 p.
aetiology, childhood leukaemia, adenovirus, prenatal infection
IdentifiersURN: urn:nbn:se:umu:diva-35028DOI: 10.1038/sj.bjc.6605581PubMedID: 20197772OAI: oai:DiVA.org:umu-35028DiVA: diva2:328339