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Effects of pharmacological and non-pharmacological interventions.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Pulmonary Medicine.
2010 (English)In: The clinical respiratory journal, ISSN 1752-699X, Vol. 4 Suppl 1, 41-48 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Asthma is recognised as a condition with variable airway obstruction with pathophysiological features that include activation of a wide range of inflammatory and structural cells. Additionally, structural changes in the airways have been demonstrated. This includes increased thickening of components in the basement membrane region, increased smooth muscle mass, increased vascularisation and many other events that is often referred to as remodelling of the airways. These processes and the underlying mechanisms have attracted considerable attention. METHODS AND RESULTS: This review describes the different interventive approaches that have been tried in order to improve asthma control and affect the underlying pathophysiological pathways. These include elimination of harmful environmental and occupational exposures, a wide range of pharmacological agents as well as bronchial thermoplasty. The existing evidence for effects on airway inflammation and airway remodelling is discussed in relationship to mechanistic aspects and short- and long-term outcome. CONCLUSION: It is expected that modulation of the asthmatic airway remodelling will become an even more important endpoint in the near future.

Place, publisher, year, edition, pages
Wiley Blackwell , 2010. Vol. 4 Suppl 1, 41-48 p.
Keyword [en]
airway mucosa, pharmacology, thermoplasty, TNF-alpha, treatment
National Category
Respiratory Medicine and Allergy
Research subject
Lung Medicine
URN: urn:nbn:se:umu:diva-35691DOI: 10.1111/j.1752-699X.2010.00196.xISI: 000276695800007PubMedID: 20500609OAI: diva2:346305
Available from: 2010-08-31 Created: 2010-08-31 Last updated: 2011-01-11Bibliographically approved

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