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Long-term rivastigmine treatment in a routine clinical setting.
Umeå University, Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine.
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2009 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 119, no 3, 180-185 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of the study was to observe the effects of long-term rivastigmine treatment in patients with mild to moderate Alzheimer's disease (AD) in a routine clinical setting. METHODS: This was a prospective, open-label, observational, multicentre, non-randomized study. Outcome measures included the Mini Mental State Examination (MMSE), the Clinician's Interview-Based Impression of Change (CIBIC) and the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog). RESULTS: Of 217 patients initiated into rivastigmine treatment, 62% (n = 135) remained on treatment for 24 months. Most patients droped out due to nursing home placement or side effects. Eighty per cent and 67% of completers exhibited a symptomatic attenuation of cognitive decline (< or = 4-point deterioration) as assessed by using the MMSE and ADAS-cog respectively. Forty-four per cent showed an unchanged/improved CIBIC rating. CONCLUSIONS: Over 60% of patients remained on treatment for 2 years in this routine clinical setting. In patients who remained on treatment, rivastigmine appeared to stabilize their condition and prevented or delayed symptomatic decline.

Place, publisher, year, edition, pages
Wiley Blackwell , 2009. Vol. 119, no 3, 180-185 p.
Keyword [en]
Alzheimer’s disease, rivastigmine, dementia
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URN: urn:nbn:se:umu:diva-35782DOI: 10.1111/j.1600-0404.2008.01086.xPubMedID: 18759798OAI: diva2:347194
Available from: 2010-09-02 Created: 2010-09-02 Last updated: 2011-01-25Bibliographically approved

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