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Partners in time: EARLY BIRD reveals novel regulatory function of ZEITLUPE in the Arabidopsis clock
Umeå University, Faculty of Science and Technology, Department of Plant Physiology. (Maria E. Eriksson)
Department of Plant Sciences, Oxford University, UK.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
Umeå University, Faculty of Science and Technology, Department of Plant Physiology.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

The circadian clock of the model plant Arabidopsis thaliana is made up of acomplex series of interacting feedback loops whereby proteins regulate their ownexpression across day and night. early bird (ebi) is a circadian mutation that causesthe clock to speed up: ebi plants have short circadian periods, early phase of clockgene expression and are early flowering. We show that EBI associates with ZEITLUPE (ZTL), known to act in the plant clock as a post-translational mediator of protein degradation. However, EBI is not degraded by its interaction with ZTL. Instead, EBI acts in opposition to ZTL, modulating the expression of key circadiancomponents. The partnership of EBI with ZTL reveals a novel mechanism involved incontrolling the complex transcription-translation feedback loops of the clock. Thiswork highlights the importance of cross-talk between the ubiquitination pathway andtranscriptional control for regulation of the plant clock

Keyword [en]
Circadian clock, Arabidopsis
National Category
Biochemistry and Molecular Biology
Research subject
Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-35860OAI: oai:DiVA.org:umu-35860DiVA: diva2:349775
Available from: 2010-09-08 Created: 2010-09-08 Last updated: 2010-11-09Bibliographically approved
In thesis
1. The circadian clock in annuals and perennials: coordination of Growth with Environmental Rhythms
Open this publication in new window or tab >>The circadian clock in annuals and perennials: coordination of Growth with Environmental Rhythms
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Since the first signs of life on planet earth, organisms have had to adapt to the daily changes between light and dark, and high and low temperatures. This has led to the evolution of an endogenous time keeper, known as the circadian clock. This biological timing system helps the organism to synchronize developmental and metabolic events to the most favorable time of the day. Such a mechanism is of considerable value to plants, since they in contrast to animals cannot change location when the environment becomes unfavorable. Thus is the ability to predict coming events of central importance in a plants life. This thesis is a study of the molecular machinery behind the clockwork in the small weed plant Arabidopsis thaliana as well as its close relative perennial; the woody species Populus. We have characterized a novel component of the circadian clock, EARLY BIRD (EBI). EBI is involved in transcriptional and translational regulation, via interaction with the known post-translational clock regulator ZEITLUPE (ZTL). In Populus, we describe the role of the circadian clock and its components with respect to entry and exit of dormancy and show that gene expression of the Populus LATE ELONATED HYPOCOTYL (LHY) genes are crucial importance for freezing tolerance and thereby survival at high latitudes. Furthermore, the input to the Populus clock is mediated via the phytochrome A (phyA) photoreceptor.

Abstract [sv]

Liv på jorden har alltid behövt anpassa sig till de dagliga växlingarna mellan främst ljus och mörker. Detta har lett till evolutionen av en intern, biologisk klocka, känd som den circadianska klockan, efter latinets ”circa diem”, som betyder ”ungefär en dag”. Denna inre klocka hjälper organismer att styra biologiska processer till den tid på dygnet som är mest gynnsam för deras utveckling och överlevnad. Denna mekanism är av stort värde för växter, eftersom de inte kan söka skydd på mera lämpliga platser om de blir utsatta för olika former av stress. Det gör att förmågan att förutse kommande händelser är av yttersta vikt för växter. Denna avhandling är en studie av det molekylära nätverk som styr denna biologiska klocka i den lilla örtplantan Arabidopsis thaliana (backtrav), och den besläktade träd-arten Populus (hybrid-asp). Vi har karaktäriserat en ny komponent i den circadianska klockan i Arabidopsis, EARLY BIRD (EBI). EBI är involverad i transkriptionell och translationell reglering av klockan, via interaktion med den kända post-translationella klock-regulatorn ZEITLUPE (ZTL). I Populus har vi beskrivit den interna klockan och dess roll i processer som invintring, vinterdvala och återstart av tillväxt. LATE ELONATED HYPOCOTYL (LHY) generna i Populus är avgörande för förvärv av köld-tolerans och således överlevnad på högre latituder. Dessutom har vi visat att signaler till den circadianska klockan i Populus är medierade via fotoreceptorn phytochrome A (phyA).

Place, publisher, year, edition, pages
Umeå: Umeå Universitet, Institutionen för fysiologisk botanik, 2010. 61 p.
Keyword
circadian clock, arabidopsis, populus
National Category
Biochemistry and Molecular Biology Plant Biotechnology Botany
Research subject
Molecular Biology
Identifiers
urn:nbn:se:umu:diva-35870 (URN)978-91-7459-062-3 (ISBN)
Public defence
2010-10-01, KB3B1, KBC-huset, Umeå universitet, Umeå, 10:00 (English)
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Supervisors
Available from: 2010-09-10 Created: 2010-09-08 Last updated: 2010-09-10Bibliographically approved

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