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Catch-Bond behavior of bacteria binding by slip bonds
Umeå University, Faculty of Science and Technology, Department of Physics.
Umeå University, Faculty of Science and Technology, Department of Physics.
2010 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 99, no 5, 1331-1341 p.Article in journal (Refereed) Published
Abstract [en]

It is shown that multipili-adhering bacteria expressing helix-like pili binding by slip bonds can show catch-bond behavior. When exposed to an external force, such bacteria can mediate adhesion to their hosts by either of two limiting means: sequential or simultaneous pili force exposure (referring to when the pili mediate force in a sequential or simultaneous manner, respectively). As the force is increased, the pili can transition from sequential to simultaneous pili force exposure. Since the latter mode of adhesion gives rise to a significantly longer bacterial adhesion lifetime than the former, this results in a prolongation of the lifetime, which shows up as a catch-bond behavior. The properties and conditions of this effect were theoretically investigated and assessed in some detail for dual-pili-adhering bacteria, by both analytical means and simulations. The results indicate that the adhesion lifetime of such bacteria can be prolonged by more than an order of magnitude. This implies that the adhesion properties of multibinding systems cannot be directly conveyed to the individual adhesion-receptor bonds.

Place, publisher, year, edition, pages
2010. Vol. 99, no 5, 1331-1341 p.
Keyword [en]
Catch bond, slip bond, multipili, cooperative, binding, bacterium, adhesion, in vivo
National Category
Biophysics
Research subject
Physical Biology
Identifiers
URN: urn:nbn:se:umu:diva-36157DOI: 10.1016/j.bpj.2010.06.003ISI: 000281721500002OAI: oai:DiVA.org:umu-36157DiVA: diva2:352421
Available from: 2010-09-21 Created: 2010-09-21 Last updated: 2017-12-12Bibliographically approved

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Björnham, OscarAxner, Ove

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