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Large-scale parent-child comparison confirms a strong paternal influence on telomere length
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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2010 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 18, no 3, 385-389 p.Article in journal (Refereed) Published
Abstract [en]

Telomere length is documented to have a hereditary component, and both paternal and X-linked inheritance have been proposed. We investigated blood cell telomere length in 962 individuals with an age range between 0 and 102 years. Telomere length correlations were analyzed between parent-child pairs in different age groups and between grandparent-grandchild pairs. A highly significant correlation between the father's and the child's telomere length was observed (r=0.454, P<0.001), independent of the sex of the offspring (father-son: r=0.465, P<0.001; father-daughter: r=0.484, P<0.001). For mothers, the correlations were weaker (mother-child: r=0.148, P=0.098; mother-son: r=0.080, P=0.561; mother-daughter: r=0.297, P=0.013). A positive telomere length correlation was also observed for grandparent-grandchild pairs (r=0.272, P=0.013). Our findings indicate that fathers contribute significantly stronger to the telomere length of the offspring compared with mothers (P=0.012), but we cannot exclude a maternal influence on the daughter's telomeres. Interestingly, the father-child correlations diminished with increasing age (P=0.022), suggesting that nonheritable factors have an impact on telomere length dynamics during life.

Place, publisher, year, edition, pages
Basel: Karger , 2010. Vol. 18, no 3, 385-389 p.
Keyword [en]
telomere length, heredity, gender, age
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:umu:diva-36324DOI: 10.1038/ejhg.2009.178ISI: 000274601800019PubMedID: 19826452OAI: oai:DiVA.org:umu-36324DiVA: diva2:353721
Available from: 2010-09-28 Created: 2010-09-28 Last updated: 2017-12-12Bibliographically approved

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Nordfjäll, KatarinaSvenson, UlrikaNorrback, Karl-FredrikAdolfsson, RolfRoos, Göran
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