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Transferrin C2, metal binding and Alzheimer's disease.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
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1998 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 9, no 2, 177-9 p.Article in journal (Refereed) Published
Abstract [en]

Significant associations between the transferrin (TF) variant C2 and a number of disorders suspected to be caused by oxygen free radicals have been reported. Thus an increased frequency of the TFC2 variant has been found in patients with Alzheimer's disease (AD), and it has been hypothesized that AD is caused by free radical damage due to defective binding of iron and aluminium by TFC2. In a study of 64 patients with AD from northern Sweden we were able to confirm the association between TFC2 and AD, but there were no significant differences between TFC2 and other TF variants with respect to the binding of iron and aluminium.

Place, publisher, year, edition, pages
1998. Vol. 9, no 2, 177-9 p.
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URN: urn:nbn:se:umu:diva-36368PubMedID: 9507951OAI: oai:DiVA.org:umu-36368DiVA: diva2:353965
Available from: 2010-09-29 Created: 2010-09-29 Last updated: 2017-12-12

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