Relationship between prophylactic effect of lithium therapy and family history of affective disorders.
1997 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 42, no 6, 425-433 p.Article in journal (Refereed) Published
Lithium therapy response and age of onset (AOO) were studied in 98 patients with bipolar affective disorder (BPAD) who were divided into subgroups depending on type of family history of affective disorders. The highest (33.0 years) and lowest (25.5 years) age of onset were found in nonfamilial patients and in familial patients with a first-degree relative of BPAD, respectively. Nonfamilial patients showed the best response to lithium. There were 0.9 episodes/year off lithium compared to 0.3 episodes/year on lithium (an 88% decrease). A poorer response (a 71% decrease; a reduction from 1.39 episodes per year off lithium to 0.65 on lithium) was found in familial patients with a first-degree relative of BPAD. Differences in serum lithium values between the groups could not explain the observed differences. Thus, familial patients showed a more severe manifestation of the disease with an earlier AOO and a lower prophylactic effect of lithium.
Place, publisher, year, edition, pages
1997. Vol. 42, no 6, 425-433 p.
Lithium therapy, age of onset, family history, anticipation, lithium prophylaxis, lithium response
Research subject Psychiatry
IdentifiersURN: urn:nbn:se:umu:diva-36369DOI: 10.1016/S0006-3223(96)00374-5PubMedID: 9285078OAI: oai:DiVA.org:umu-36369DiVA: diva2:353983