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Platelet [3H]paroxetine binding to 5-HT uptake sites in Alzheimer's disease.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Psychiatry.
1991 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 12, no 5, 531-4 p.Article in journal (Refereed) Published
Abstract [en]

Platelet serotonin (5-hydroxytryptamine, 5-HT) uptake sites were studied in a control group (n = 30) and an Alzheimer group (n = 40) using [3H]paroxetine as radioligand. The maximum number of binding sites (Bmax) for control (1250 +/- 60 fmol/mg protein) was not different from the Alzheimer group (1280 +/- 40 fmol/mg protein). There were no differences in apparent binding affinity (Kd): 0.046 (0.024-0.062) nM for control and 0.040 (0.027-0.061) nM for Alzheimer. Thus even though several previous studies have demonstrated marked atrophy of 5-HT containing neurites and 5-HT uptake sites in Alzheimer's disease, these findings are not found in the periphery on platelets. The platelet 5-HT uptake site cannot be used as a peripheral marker of Alzheimer's disease.

Place, publisher, year, edition, pages
1991. Vol. 12, no 5, 531-4 p.
URN: urn:nbn:se:umu:diva-36381PubMedID: 1837595OAI: diva2:354015
Available from: 2010-09-29 Created: 2010-09-29 Last updated: 2011-05-17

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